World Journal of
Pharmaceutical and Life Sciences

ASSESMENT OF MICROBIAL QUALITY OF SOME PHARMACEUTICAL SYRUPS AVAILABLE IN UYO LGA OF AKWA IBOM STATE

Akeem Agboke* and Nneoma Igbokwe

ABSTRACT

This study was designed to evaluate the microbial quality of some pharmaceutical syrups available in Uyo LGA, Akwa Ibom. The microbiological quality of 10 different syrup samples of 10 pharmaceutical companies was assessed. The total aerobic microbial count (TAMC) varied between 1.0×103 CFU/ml and 6.0×103 CFU/ml.The total yeast and mold count (TYMC) ranged from 1.0×103 CFU/ml to 2×103 CFU/ml. In general, the microbiological qualities of six (6) which is 60% of the syrups tested have viable bacterial load within USP acceptable limits while four (4) which is 40% fell above stipulated standards. None of the syrups tested contained objectionable microbe (E.coli). Three samples of the syrups did not contain any mould while five samples of the syrups contained moulds which were within acceptable limits of USP. Two samples of the syrups contained moulds well above the stipulated standard. This work showed that quality of syrups that conformed to the standards was well prepared according to Current Good Manufacturing Practice (CGMP), while some might be contaminated during distribution and storage.

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