World Journal of
Pharmaceutical and Life Sciences

CORRELATION OF RANDOM URINARY CALCIUM/CREATININE RATIO WITH 24- HOUR URINE CALCIUM IN 2-16 YEAR OLD IN-PATIENTS OF BANDAR ABBAS PEDIATRIC HOSPITAL IN 2015

Kambiz Ghasemi*, Maryam Esteghamati and Arezoo Masroor

ABSTRACT

Background: Calcium is the best known ion in the skeletal muscular system of body and kidneys are the key organ for calcium hemostasis. As collecting 24-hour urine samples is hard and time-consuming among young adults and children, measuring non-fasting random urinary calcium/creatinine ratio can be very practical to identify individuals with a high urinary calcium excretion. The present research aims to explore the correlation between 24- hour urine calcium with random urinary calcium/creatinine ratio in terms of patients’ age and gender in Bandar Abbas Hospital in 2015. Methods: The present cross-sectional research is descriptive and analytical in type. It was conducted on 228 patients between 2 and 16 years of age staying in Bandar Abbas pediatric hospital in 2015. The research sample was selected in a simple randomized convenient sampling method from the target population. Calcium level was measured via Cresolphtalen Complexion Spectrophotometrics while creatinine level was measured through Kinetic Jaffe Reaction via Hitachi autoanalytic device. Finally, UCR/CR was measured manually. Results: In this research, 228 patients participated who were between 2 and 16 years of age, whose calcium/creatinine ratio was measured and statistically analyzed. From among them, 127 (55.7%) were male while 101 (44.3%) were female. The highest random urinary calcium/creatinine ratio was 3.55 while the lowest ratio was .21 (mean: .39 SD±.49). The lowest rate of urine calcium excretion was 1.88 mg/Kg/day within 24 hours while the highest rate was 10.91 mg/Kg/day in 24 hours. Conclusion: The present research revealed that collecting 24-hour urine samples is a gold standard in diagnosing hypercalciuria and should be used to diagnose patients with this disease.

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