World Journal of
Pharmaceutical and Life Sciences

PREVALENCE OF NEONATAL CANDIDEMIA IN TERTIARY CARE INSTITUTE, INDORE

Dr. Apoorwa Gupta* and Jitendra Gupta

ABSTRACT

Background: Candida spp.is one of the most frequent pathogens isolated in bloodstream infections (BSI), and is associated with significant morbidity and mortality in hospitalized patients1 .Candida species are known to be the most common fungal pathogens isolated from blood cultures of neonates. Recent reports from our country indicates trend towards an increasing prevalence of non-albicans Candidemia. Candida species possess a number of virulence factors which enable them to cause hematogenously disseminated infections in susceptible hosts with increased morbidity and mortality. Objectives: To know the prevalence of candidemia in neonates and their antifungal susceptibility pattern. Materials and Methods: Blood samples from suspected cases of neonatal septicemia were subjected to culture, incubated in BacT-Alert a automated machine and subcultures performed. Culture yielding pure growth of Candida were included for the study and identified by standard methodology. Antifungal susceptibility was performed by disc diffusion method on Muller-Hinton agar with 2% glucose and methylene blue. Statiscal Analysis: no Result: A total of 180 cases were blood cultures positive. Pure growth of Candida species was isolated from 34 (18.8%) cases. A total of 34 Candida isolates were obtained over a period of one year accounting for 18.8% of all neonatal septicemia cases. Among 34 isolates, C.glabrata 14(41.1%), C. krusei 8 (23.5%), C.albicans 11 (32.3%) and C. tropicalis 1(2.9%). Fluconazole susceptibility was observed in 22(64.7%) sensitive, and 12(35.2%) resistant and all were sensitive to Amphotericin B. Conclusion: In this study non- albicans candida was the common isolate & they showed decreased resistance to Fluconazole. In neonatal septicemia speciation & antifungal susceptibility testing may help in management.

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