World Journal of
Pharmaceutical and Life Sciences

A STUDY ON COMPARATIVE ANALYSIS OF WITHANIA SOMNIFERA (ASHWAGANDHA) WITH VALERIANA WALLICHI (TAGARA) IN RELATION TO THEIR ANTI-INFLAMMATORY ACTIVITY IN MALE ALBINO RATS

Dr. P. Jagadeesh, Dr. M. Veera Sekhar*, P. Lakshmi Deepika and Dr. P. Vijayalakshmi

ABSTRACT

Aim and objectives: the present study was carried out 1) To evaluate the anti-inflammatory activity of Withania Somnifera, Valeriana wallichi in male albino rats. 2) To compare the anti-inflammatory activity of Withania Somnifera with Valeriana wallichi in male albino rats by using Plethysmograph. Materials and methods: Male albino wistar rats of 250 to 300gm weight were randomly allotted into three groups namely Control, Test-1 and Test-2. For control group rats 0.2 ml of normal saline, for test-1 group rats Withania Somnifera in a dose of 25.69 mg/kg, for test-2 group rats Valeriana wallichi in a dose of 120mg/kg, was administered as a single oral dose half an hour before injecting 0.1ml of 1% carrageenan to the sub-plantar region of hind paw and the paw edema of each rat was measured at 3hours Results: Both the test drugs have shown significant anti-inflammatory activity (p<0.05). However Withania somnifera in a dose of 25.69 mg/kg showed significantly higher anti-inflammatory effect than V.wallachi given in a dose of 120mg/kg. Conclusion: Withania somnifera and Valeriana wallachi have significant anti-inflammatory activity.

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