World Journal of
Pharmaceutical and Life Sciences

POTENTIAL OF CURCUMA LONGA TO AMELIORATE PESTICIDE INDUCED GENOTOXICITY AND OXIDATIVE STRESS – STUDY ON CAPTAN, AN ORGANOCHLORINE FUNGICIDE

Dr. Dhanya K. Chandrasekharan*, Souda Ali Ahamed M. and Nusrath Noorudheen

ABSTRACT

Pesticides are some of the most frequently released toxic chemicals into the environment to enhance crop productivity and control insect-vector borne diseases. Eventhough and pesticides are in a way beneficial, their increased use has several drawbacks including health effects, loss of bio-diversity and irreversible changes in natural ecosystems. Around the world, approximately 3 million poisonings from pesticide exposure are reported annually. The present study report the genotoxic effect of a commercially available fungicide, Captan. DNA damage analysis by comet assay was performed in human peripheral blood lymphocytes, chromosomal aberration analysis was performed in onion (Allium cepa) root tips and assay of DNA damage and oxidative stress indicators was done in Guppy (Poecilia Reticulata). The potential of a nutraceutical, Curcuma longa was evaluated for its ability to protect against Captan and induced genotoxicity and oxidative stress in the above experimental models.

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