World Journal of
Pharmaceutical and Life Sciences

STUDIES ON FORMULATION AND CHARACTERIZATION OF TOPICAL GEL CONTAINING MICROSPONGES OF MEFENAMIC ACID

Shuhaib B.* and Dr. Suja C.

ABSTRACT

The objective of the present investigation was formulate & characterize the microsponge of mefenamic acid, these microsponges were prepared by quassi-emulsion method. Preformulation studies by FTIR, revealed no interaction between pure drug and the different polymers used. The prepared microsponges were characterized for their production yield, drug content, mean particle size & entrapment efficiency, Effect of formulation variable were also studied. The microsponge containing 0.5 gm of poly vinyl alcohol, 0.6 gm of ethyl cellulose and 5ml ethanol good were compared to the other formulation prepared The best microsponges (M3, M6, M9) in cooperated into gel. The topical gel was evaluated for their organoleptic characters, viscosity, spreadability, drug content and drug release studies. From that MG2 Shows better compared to other formulation. The various release kinetics were studied from that gel have the drug release seems to follow zero order kinetics as it is evidenced by correlation coefficients (r2=0.9907 to 0.9658) which is better than first order (r2 = 0.970 to 0.88) in mefenamic acid microsponge gel. Drug permeation from mefenamic acid gel followed Higuchi model or matrix diffusion.

[Full Text Article]   [Download Certificate]