World Journal of
Pharmaceutical and Life Sciences

HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES OF FICUS HISPIDA FRUITS AND BARK IN ALLOXAN INDUCED DIABETIC RATS

Ariful Islam, Most. Naoshia Tasnin, Md. Dobirul Islam, Md. Monirul Islam, Shamima Nasrin, M. Ismail Hossain, Mohammad Amirul Islam and *Masudul Hasan Khan

ABSTRACT

Now a day’s diabetes mellitus is one of the most common health problems. Retinopathy, nephropathy, angina pectoris, heart attack, transient ischemic attacks, strokes and peripheral arterial disease are the common complication of diabetes. Traditionally Ficus hispida Linn. (F. hispida) is used in herbal medicine for the treatment of diabetes for many years, but there is no sufficient data for its antidiabetic property. This study was undertaken to evaluate the antidiabetic and antihyperlipidemic activities of ethanol extracts of F. hispida fruits and bark in alloxan-induced diabetic rats. The results showed that F. hispida fruits and bark decreased blood glucose level significantly (P<0.001 to P<0.01) and also regulated parameters of lipid profile (TG, TC, LDL, VLDL, HDL) significantly (P<0.001 to P<0.01) in experimental model ofdiabetes mellitus. The levels of serum SGPT, SGOT and CRP were also adjusted to the normal levels notably (P<0.001 to P<0.01) by the intraperitoneal administration of ethanol extract of F. hispida bark (EB) and ethanol extract of F. hispida fruits (EF).Further studies are required to be done to isolate the active compounds from the F. hispida fruits and bark, elucidate their structures and their mode of action.

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