World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ANALGESIC ACTIVITY OF ETHANOLIC AND AQUEOUS EXTRACTS OF ABUTILON INDICUM IN ALBINO MICE

Dhanapal Venkatachalam*, Sampath Kumar K. P. and Anil Middha

ABSTRACT

Pain as a sensory modality; represent a symptom for diagnosing various diseases and its associated conditions. Conventional synthetic drugs that are used to manage pain are not readily available and are associated with adverse effects. Thus, the use of herbal medicine from medicinal plants is an age old practice used by many communities to cure diseases. These medicinal plants are known to contain phytochemical compounds capable of relieving pain and healing diseases. The present study aims to investigate the analgesic activity of the Ethanolic and Aqueous extracts of Abutilon indicum in albino mice using, Acetic acid-induced abdominal writhing and hot plate analgesic models in albino Wistar mice were used for the study. The extracts were administered intraperitoneally at a dose of 50 mg/kg and 100mg/kg while Diclofenac sodium 10mg/kg and pentazocine 5mg/ served as standard in Acetate induced abdominal writhing and hot plate, method respectively.. The results are analysed by one way ANOVA followed by Dunnet’s test The Ethanolic extract of 100mg /kg having significant analgesic activity in Acetic acid induced abdominal writhing response and percentage of inhibition (PI) (p<0.01 )when compared to control.. The Ethanolic extract of 50mg/kg and 100mg/kg exhibited significant analgesic activity in the hot plate method (p<0.001) by increasing the pain reaction time(PAT) of the rats to sec 7.25±0.38 at 45 min after treatment in comparison to control (4.08±13)

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