World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF WOUND HEALING POTENTIAL OF ETHANOLIC LEAVE EXTRACTS OF GMELINA ARBOREA ROXB IN WISTAR RATS

*Sangram Keshari Panda, Subhashree Padhy and Sidhartha Sankar Padhy

ABSTRACT

Gmelina arborea Roxb. commonly known as Gambhari belong to family (Verbenaceae) is a medicinal tree and its leaves, stem bark, fruits, roots, flowers all are used for medicinal purpose in India since ancient times.Leaf paste is applied to relieve headache and juice is used as wash for ulcers.The present study was an attempt to investigate the wound healing potential of Gmelina arborea leave extract in two different types of wound models in albino rats viz., incision and excision. The various leave extracts of G.arborea such as ethanol, ethyl acetate ,methanol and petroleum ether were obtained by successive solvent extraction. The standard drug (povidone iodine ointment) applied topically and all the extracts (250 mg/Kg) of G.arborea leaves were given orally.The ethanolic extract showed significant increase in wound contraction and formation of scar in excision wound model.The extract showed significant increase in the breaking strength of resutured incision wound as compared to control group (p<0.05).The result of the present study indicate that the ethanolic extract of G.arborea leave shows more significant wound healing property than the other three extracts in excision and incision wound model.

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