World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

IN VIVO SEDATIVE ACTIVITY OF ETHANOL AND AQUEOUS EXTRACTS OF STEM OF ABUTILON INDICUM

Dhanapal. V.*, Samuel Thavamani B., Muddukrishniah and Sampath Kumar

ABSTRACT

Insomnia is one of the most common sleep disorders around the world. In this present study we evaluate the crude ethanol and aqueous extract of stem of Abutilon indicum, a medicinal plant which is laxative, anticonvulsant, diuretic, etc., using phenobarbitone-induced sleeping time test in mice. Ethanol extract produced a significant (p>0.05) and dose dependent reduction in the onset of sleeping and aqueous extract of 100 mg/kg and 200 mg/kg was significant in prolonging the sleeping time. These results suggest that the fraction obtained from the aqueous extract of stem of Abutilon indicum posses sedative activity may further lead to the pharmacological and pharmacokinetics of the plant to a useful sedative in future.

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