World Journal of
Pharmaceutical and Life Sciences

ROLE OF GENETICS AND IMMUNOLOGICAL ASPECTS IN RECURRENT APTHOUS STOMATITIS

*Divya Pandya MDS, Soumik Roy MDS and Tapas Kumar Sarkar MDS

ABSTRACT

Recurrent apthous stomatitis (RAS) is a chronic inflammatory, ulcerative condition of the oral mucosa. The etiopathogenesis of the disease is considered to be multifactorial, but remains still not fully understood. In patients with RAS, an enhanced immunologic response occurs to some trigger factors including mechanical injury, stress or bacterial and viral antigens. Higher prevalence of apthae in relatives may also indicate the genetic background of the condition. The inheritance of some specific gene polymorphism, especially those encoding proinflammatory cytokines that plays a role in formation of apthous ulcer, may also predispose family members to RAS. The results of currently performed studies indicate that genetically mediated disturbances of the innate and acquired immunity play an important role in disease development. The aim of this paper is to emphasize on the involvement of genetics and immunological factors as one of the important but least discussed etiology of apthous.

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