World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF SUDANESE SOLANUM INCANUM L. (SOLANACEAE) FIXED OIL

Dr. Abdel Karim M.*, Inas A. and Dalia O.

ABSTRACT

The present study was designed to investigate the chemical constituents of Solanum incanum seed oil and to evaluate its potential antimicrobial activity. GC-MS showed the presence of 27 components. Major constituents are: 9,12-Z,Z-octadecadienoic acid methyl ester (31.65%),9-Z-octadecenoic acid methyl ester(19.46%%), hexadecanoic acid methyl ester(12.39%), campesterol(10.22%), 2,6-bis-(2,4-methylenedioxyphenyl)-3,7-dioxabicyclo(3.3.0) Octane(6.49%), methyl stearate(3.90%), gamma sitosterol(3.02%). The antimicrobial activity of the oil was evaluated via cup plate agar diffusion assay against five standard human pathogens (Gram positive: Staphylococcus aureus and Bacillus subtilis; Gram negative: Escherichia coli and Pseudomonasa aeruginosa and the yeast Candida albicans. The oil gave significant activity against Pseudomonas aeruginosa. It also showed excellent activity against Staphylococcus aureus and Escherichia coli. However, it exhibited weak anticandidal activity.

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