World Journal of
Pharmaceutical and Life Sciences

ZINC AND VITAMIN-E IMPACT ON CADMIUM INDUCED BIOACCUMULATION IN LIVER AND KIDNEY OF MALE ALBINO RAT

Dr. Obaiah Jamakala*

ABSTRACT

Cadmium (Cd) is a toxic, non-essential and industrial pollutant. The aim of the present work is to know the zinc (Zn) and vitamin-E impact on Cd induced bioaccumulation in liver and kidney of Cd treated rats. Wistar strain male albino rats were treated with cadmium chloride at a dose of 1/10th LD50 / 48h i.e. 22.5 mg/Kg body weight for 7, 15 and 30 days (d) time intervals. Then 15d Cd treated rats were divided into three groups. The first group received Zn (12 mg/Kg), second group vitamin-E (300 mg/Kg) alone and third group supplemented with both Zn and vitamin-E for again 7, 15 and 30d long sojourn. After the specific time intervals, rats were decapitated and tested for Cd bioaccumulation levels by Atomic Absorption Spectrophotometer (AAS – Schimadzu AA6300). There was a significant elevation in Cd concentrations in both the test tissues with increased period of Cd treatment. Maximum Cd accumulation was found in 30d Cd treated rat kidney (32.78 ± 0.29?g / gm). However there was a significant reduction in Cd bioaccumulation with Zn and vitamin-E supplementation. Maximum decrease in Cd accumulation was found in 30d rat kidney (8.62±0.15?g / gm) supplemented with the combination of Zn and vitamin-E. Our findings clearly envisage that combined supplementation of Zn and vitamin-E is more effective in reducing the Cd body burden when compared to the other modes of supplementation.

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