World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ANTIMICROBIAL ACTIVITY OF THUJA OCCIDENTALIS EXTRACT AGAINST SOME HUMAN PATHOGENIC BACTERIA

Amit Dubey, Dr. Wasim Raja* and Yashasvi Bairagi

ABSTRACT

The present study was conducted to evaluate the antimicrobial activity of methanolic extract of Thuja occidentalis. In vitro antimicrobial activity was tested by agar well diffusion assay against human pathogenic microbes which are gram negative bacteria; Acetobactor, Citrobactor and E. coli and gram positive bacteria; Bacillus subtilis, S. aureus and Enterobacter and fungi (Rhizopus orgae, Ponicillium griseofulvm, Fusarium solani and Alterneria alternate) were evaluated. This study show that methanolic extract of Thuja occidentalis inhibits the growth of micro organism dose dependently. A significant correlation was observed between zone of inhibition and concentration of extract. These results confirm the antimicrobial activity of Thuja occidentalis and support the traditional use of the plant in therapy of bacterial infection. These promising findings suggest the presence of antibacterial activity in the tested plant material, exhibited by its bioactive compounds, and serving them as an alternative antimicrobial agent. Thus, Thuja occidentalis could be considered as potential source of natural antimicrobials used for the treatment of bacterial and fungal infections.

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