World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

ANTIFUNGAL ACETYLATED FLAVONOL FROM THE SUDANESE MATERIAL OF VANGUERIA MADAGASCARIENSIS RUBIACEAE

Prof. Abdel Karim*, M. Dalia, A. Kamal, M. S. and Khalid M. S.

ABSTRACT

The authors report on the isolation of a flavonol from the Sudanese material of Vangueria madagascariensis. The flavonoid was isolated from the ethanolicextract by column and thin layer chromatography. The structure was elucidated by a combination of analytical tools (UV, IR, 1H NMR, 13C NMR and MS). In cup plate agar diffusion assay, compound I and the chloroform fraction of Vangueria infausta were evaluated for their antimicrobial activity against six standard human pathogens (Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger). The chloroform fraction did not show antibacterial activity, but it showed significant inhibitory activity against the fungi: Candida albicans and Aspergantillus niger. Compound I also showed antifungal activity. However, it did not reveal antibacterial activity.

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