World Journal of
Pharmaceutical and Life Sciences

CONCEPT OF PATHOGENESIS OF DHATVAGNIVIKARA W.S.R. TO HYPOTHYROIDISM AND THERAPEUTIC EVALUATION OF TRIKATU CHURNA AND KANCHANARA KWATHA

Dr. Mamta Kumari*, Dr. Surendra Kumar Sharma and Dr. Reetu Sharma

ABSTRACT

Hypothyroidism refers to the under activity of thyroid gland resulting into deficiency of thyroid hormone which may be considered as malfunctioning of agni (pitta). In india 42 million people are suffering from thyroid disorders out of which hypothyroidism is most common with prevalence of 5.4% Sixty uncomplicated cases of hypothyroidism were selected randomely irrespective of their age, sex, education etc. from O.P.D. and I.P.D. of Arogyashala, National Institute of Ayurveda, Jaipur. Inclusion criteria age 18 to 80years, either sex, TSH value more than normal value. Exclusion criteria patient with major psychosis and other critical illness pregnant women, psychiatric illness Diagnostic Criteria – Weakness, Tiredness, Drowsiness, Weight, Deepend gruf voice, swelling neck, Aches and pains muscle stiffness and muscle pain, Dry/Rough Skin. Investigation- CBC, LFT, RFT, LIPID PROFILE, Sr.TSH, Sr.T4, Sr.T3. Group-A -30 patient recommended for Trikatu churna(3gm bd) and kanchnara kwatha(40ml bd) for 12 weeks Group B, 30 patient recommended Tab Thyroxine sodium as prescribed by physician. clinical recovery in 30 patient treated with Trikatu churna and kanchnara kwatha (group A) Weakness p= 0.005121,Tiredness p = 0.014956,Drowsiness p = 0.000202,Weight p = 0.036787,Deepened gruff voice p = 0.014956, Neck swelling p = 0.023856, Aches and pain p = 0.023856,muscle stiffness p= 0.024846,Dry/rough skin p =0.024846,Swelling all over body p = 0.036787,Constipation p = 0.000959,cold intolerance p = 0.001323, Breathlessness p = 0.000136,In group B clinical recovery Weakness p =0.00034,Tiredness p = < 0.0001,Drowsiness p =0.00037,Weight p= 0.00017,Deepened gruff voice p = 0.01070,Neck swelling p = 0.00311,Aches and pain p = 0.00311,muscle stiffness p = 0.00109,Dry/rough skin p = 0.00377,swelling all over body p = 0.00946,highly significant in group B significant in group A. Discussion- While assessing the clinical recovery in all the patients of Hypothyroidism of two groups it was observed that the patients receiving only allopathic drug i.e. Tab Thyroxine showed some amount of growing feeling of wellbeing after the therapy. And those patients who were put on purely Ayurvedic drug also witnessed a significant feeling of well-being the percentage of improvement was maximum in group B (HS) and significant in group A.

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