World Journal of
Pharmaceutical and Life Sciences

TOXICITY STUDY OF THE AQUEOUS EXTRACT OF TEUCRIUM CAPITATUM L AND SILENE VULGARIS OF THE EL HAJEB REGION (CENTRAL MOROCCO)

Jalila El Amri*, Khalid El Badaoui and Redouane Tarik

ABSTRACT

In this study, we studied the acute toxicity of the aqueous extract of two plants Teucrium capitatum L and Silene vulgaris, selected from an ethnobotanical study of the EL HAJEB region (Morocco), followed by a phytochemical, antimycobacterial and toxicity study. Administration of the aqueous extract at different doses taken orally on male and female mice to severe symptoms of toxicity. These symptoms are caused by respiratory problems, tremors, paralysis of the hind legs and comas causing death. According to the results obtained, the highest dose killing all animals or 100% lethal dose (LD100) is 9600 mg / kg / vo for Teucrium capitatum L and 4800 mg / kg / vo for Silene vulgaris. Whereas for the maximum tolerated dose (DMT) it is 1200mg / kg / vo for Teucrium capitatum L and 600mg / kg / vo for Silene vulgars. . The LD50 value (5880 mg / kg / vo) over 48 hours of observation indicates that the aqueous extract of the Teucrium capitatum L plant administered orally (VO) is almost non-toxic, for mice. The calculation of the LD50 value of the extract of Silene vulgaris gives the value of 2430 mg / kg / vo, the plant is considered to be slightly toxic.

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