World Journal of
Pharmaceutical and Life Sciences

ADENOSINE DEAMINASE: A TARGET ENZYME IN DIFFERENT PATHOLOGIES – A REVIEW

Dr. Alvard Antonyan*

ABSTRACT

Adenosine is an anti-inflammatory agent, involved in the cellular energy and purine metabolism. Its derivatives of nucleotide and nucleoside nature have both the therapeutic significance in the treatment of immune, cardio and neurodegenerative disorders, and sometimes, can posses the toxic action on the cells and mammalian tissue. Adenosine deaminase is one of the enzymes participating in inactivation of the adenosine derivatives both in the intra- and intercellular medium. Therefore, the search for the regulators of activity of adenosine deaminase is a very important task of modern pharmacology. The solution of this task demands the knowledge on the catalytic peculiarities, active site structure, interaction with the substrates and with the probable inhibitors of the enzyme. This work reviews the information on the indicated fields available to date.

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