World Journal of
Pharmaceutical and Life Sciences

1-(CARBOXY)-1-(N-ACETYLAMINO)-2-(3, 5’-DI- TRET -BUTYL-4’- HYDROXYPHENYL-PROPIONATE SODIUM PREVENTS OF OXIDATIVE STRESS IN ANIMALS AND PLANTS

Irina Zhigacheva* and Maksud Rasulov

ABSTRACT

In stress conditions, the formation of ROS by mitochondria increases, which leads to a shift in the antioxidant - prooxidant balance toward increasing the ROS content in the cell. The interaction of ROS with polyunsaturated fatty acids, which enter into the composition of the lipids of mitochondrial membranes, leads to the activation of lipid peroxidation (LPO). Herewith in 2.5 - 3 times increased fluorescence intensity of LPO products in the membranes of these organelles. Spatial-obstructed phenols, in particular, 1-(carboxyl)-1-(N-acetylamino)-2-(3’,5’- di-tret-butyl-4’-hydroxyphenyl)-propionate sodium (sodium anphen) decrease the LPO intensity to control values and increases the activity of the I complex of the mitochondrial respiratory chain, providing high functional activity of these organelles. The prevention of mitochondrial dysfunction is associated with an increase in the resistance of plant and animal organisms to stress factors.

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