World Journal of
Pharmaceutical and Life Sciences

EVALUATION OF ANTI-MITOTIC ACTIVITY OF INDOLE DERIVATIVE ON GERMINATING BENGAL GRAM SEEDS

L. Srividya, G. Kiran and Dr. A. Rama Narsimha Reddy*

ABSTRACT

Isatin and its analogs are versatile substrates, which can be used for the synthesis of numerous heterocyclic compounds. Isatin and its derivatives are used in organic synthesis and they are used in evaluating new product that possesses different biological activities. The synthetic versatility of Isatin derivatives has been draw the attention in several synthetic organic and medicinal chemists due to varied biological and pharmacological properties of such compounds. Literature survey revealed that isatin (1H-indole-2,3-dione) possesses diverse chemotherapeutic activities, such as anticancer (Gursoy and Karal, 2003), antiviral (Debra et al., 2006), anti-HIV (Pandeya et al., 1999a), anti-mycobacterial (Karal et al., 2007), antibacterial (Pandeya et al., 1999b), anti-inflammatory (Sridhar and Ramesh, 2001) and anticonvulsant (Verma et al.,2004). Among these properties, cytotoxic and antiproliferative activities of this moiety have been found to be interesting.

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