World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

SYNTHESIS, CHARACTERIZATION, ANTI-INFLAMMATORY AND ANTIMICROBIAL ACTIVITIES OF SOME NOVEL DIHYDROPYRIMIDINONE DERIVED PYRAZOLINES

Dr. Konda Ravi Kumar* and B. Lourdu Rani

ABSTRACT

A novel series of dihydropyramidinone derived pyrazoles were synthesized from dihydropyrimidinones by acid mediated method. The newly synthesized compounds were purified by recrystallization and characterized the compounds by their spectral analysis like IR, 1HNMR and Mass. Further these compounds were screened for their biological activities are anti-inflammatory and antimicrobial activities. All the compounds showed potent to moderately potent antibacterial activity. Among the compounds P 1- 22, compound 3, 4 and 21 showed potent activity and compounds 7, 8, 9, 16, 22 showed moderately potent activity antibacterial activity. Compounds 3, 9, 13 showed potent and compounds 8, 4, 15 and 18 showed moderately potent antifungal activity. Anti-inflammatory activity of synthesized compounds were evaluated against Wistar male albino rats by carrageenan induced paw edema method using indomethacin as standard drug.

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