World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF SUDANESE FOENICULUM VULGARE (APIACEAE) ESSENTIAL OIL

Prof. Abdel Karim M.*, Tamador A. A. and Khalid M. S.

ABSTRACT

Foeniculum vulgare essential oil was studied by GC-MS. The oil was also assessed for antimicrobial activity. Thirty five components were detected by GC-MS analysis. Main constituents are: (1-phenyl)-1, 2-ethanediol (21.43%), 4-(1-methyethyl) benzaldehyde(18.03%), gamma,-terpinene(15.35%), 2-caren-10-al(14.15%), and ?-pinene (10.45%). The antibacterial activity of the oil was evaluated via the diffusion assay against five standard human pathogens (Gram positive: Staphylococcus aureus and Bacillus subtitlis; Gram negative: Esherichia coli and Pseudomonasa aeruginosa and the fungus Candida albicans). Foeniculum vulgare oil showed excellent activity against all test organisms at 50mg/ml. At 25mg/ml the oil exhibited significant activity against Staphylococcus aureus and the yeast Candida albicans. The oil was active against all test organisms in the range: 50-12.5mg/ml.It seems that the oil is a lead for further optimization.

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