World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

GC-MS ANALYSIS AND ANTIMICROBIAL ACTIVITY OF SUDANESE CARUM CARVI (APIACEAE) FIXED OIL

Prof. Abdel Karim M.*, Tamador A. A. and Khalid M. S.

ABSTRACT

Carum Carvi seed oil was studied by GC-MS. The oil was also assessed for antimicrobial activity. Fourty five components were detected by GC-MS analysis. Main constituents are: 9-octadecenoic acid (z)-methyl ester (45.82%), 9,12-octadecenoic acid(z,z)-methy1 ester(15%), estragole (11.48%). The antibacterial activity of the oil was evaluated via the diffusion assay against five standard pathogenic bacteria (Gram positive: Staphylococcus aureus and Bacillus subtitlis; Gram negative: Esherichia coli and Pseudomonasa aeruginosa and the fungus Candida albicans). With the exception of Bacillus subtilis, Carum carvi oil showed activity against all test organisms at: 50-25mg/ml.The oil exhibited excellent activity against Staphylococcus aureus in the concentration range: 50-25mg/ml. At: 50mg/ml it showed significant activity against the yeast: Candida albicans

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