World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL HETEROCYCLIC CHALCONE DERIVATIVES

M. Sangeetha*, C. Rubina Reichal and N. Thirumoorthy

ABSTRACT

Chalcones are an important class of natural products and are considered as the precursors of flavonoids and isoflavonoids. Some novel heterocyclic derivatives of chalcones were synthesized by condensing benzaldehyde derivatives with hydroxyl acetophenone in dilute Ethanolic sodium hydroxide solution at room temperature according to Claisen – Schmidt condensation. The structures of these compounds were characterized by TLC, infrared spectroscopy and nuclear magnetic resonance spectroscopy. The antimicrobial activity of the novel products was evaluated by disc diffusion method. The in vitro antibacterial and antifungal screening of the chalcone derivative revealed that C4 and C6 showed potent activity.

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