World Journal of
Pharmaceutical and Life Sciences

STUDY OF ANTICANCER AND ANTIOXIDANT ACTIVITY OF WRIGHTIA TINCTORIA ROXB

Ajmera Shanthipriya*

ABSTRACT

The aim of this study was to evaluate the anticancer and antioxidant activity of the ethanolic extract of Wrightia tinctoria roxb. (Apocynaceae) in rat models. The ethanolic extract of Wrightia tinctoria roxb was prepared using 90% ethanol by (1:4) ratio, for 20 hrs. The extract was distilled and concentrated. A I.P.dose of 50, 100 mg/kg of the extract was evaluated for anti-Cancer & antioxidant activity in CMC induced Cancer rats for 14th days. The body weight, MST, AST, ALT, Ascities fluid volume and urine parameters calcium, urea, uric acid, creatinine were analyzed. Then the histopathological studies were done for determination of the kidney stones. A dosage of 200 and 400 mg/kg of the extract significantly decreased (p < 0.05) serum and urine levels components in urolithiatic rats. The histopathological study has shown low kidney stones at 200mg/kg, 400mg/kg of the extract. The obtained results have shown that the Desmostachya bipinnata ethanolic extract has anti-urolithiatic activity and detailed investigation are required by using the purified compound from the ethanolic extract of Desmostachya bipinnata.

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