World Journal of
Pharmaceutical and Life Sciences

STOMACH SPECIFIC FLOATING IN SITU GEL DRUG DELIVERY SYSTEM – A REVEIW ON PRIMARY AND NOVEL APPROACHES

Aravinda Nalla* and Krishna Mohan Chinnala

ABSTRACT

Conventional oral dosage forms pose low bioavailability problems due to their rapid gastric transition from stomach, especially in case of drugs which are less soluble at alkaline pH of intestine. The drugs which produce their local action in stomach get rapidly emptied and do not get enough residence time in stomach. So, frequency of dose administration in such cases is increased. To overcome this drawback and to maximize the oral absorption of these drugs, novel drug delivery systems have been developed such as floating systems, mucoadhesive, high density and expandable, since they provide controlled delivery of drugs with prolonged gastric residence time. In-situ gel provides the best way to overcome problems of immediate release and short gastro intestinal residence of liquids. The in situ gel dosage form is a liquid before administration and after it comes in contact with gastric contents due to one or more mechanisms gets converted to gel which floats on gastric contents. This achieves increased residence as well as sustained release. This approach is useful for systemic as well as local effect of drugs administered such as aluminum hydroxide and magnesium carbonate.

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