World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 2-NAPHTHYLACETATE MANNICH BASES

Prof. Abdel Karim M.*, Elhadi S. and Khalid M.

ABSTRACT

Using 2-naphthylacetate as active hydrogen component, the following Mannich bases were synthesized via a general synthesis protocol: 1-hydroxymethyl-1-piperidinomethyl-2-naphthylacetate(I); 1,1-dimorpholinomethyl-2- Naphthylacetate(II) and 1,1-bis-dimethylaminomethyl-2-naphthylacetate(III).The structures of the final products was elucidated by a combination of spectral techniques (UV,IR , 1HNMR and MS). The target molecules were evaluated for antimicrobial activity against six standard human pathogens. Significant activity was exhibited by compound I. It showed antimicrobial activity against all test organisms. Compounds II and III showed significant antifungal activity,

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