World Journal of
Pharmaceutical and Life Sciences

ISOLATION AND ANTIBIOTIC SUSCEPTIBILITY PATTERN OF BACTERIAL SPECIES ASSOCIATED WITH URINARY TRACT INFECTION IN ONDO STATE, NIGERIA

*Olajide Adedayo Ajayi and Felix Ijikuotu

ABSTRACT

Mid-stream urine samples were collected from adults and children of both sexes including pregnant women within Akoko Local Government area and Ondo town of Ondo State, Nigeria for microbiological analysis. 23(54.8)% of the isolates were identified as Escherichia coli, 10(23.8) % - Klebsiella, 4(9.5)% - Staphylococcus aureus, 3 (7.1)% - Proteus species and 2(4.8)% - Pseudomonas species in selected Akoko communities, Nigeria. With specificity to pregnant women in Ondo community, Nigeria, forty (40) bacterial species isolated and diagnosed include, Escherichia coli, 11 (26.49 %) Pseudomonas aeruginosa 10 (24.50 %), Staphylococcus aureus, 6 (15.00%), Proteus vulgaris, 2 (5.00%), Proteus mirabilis, 5 (12.50%), Klebsiella pneumonia, 2 (5.00%), Coagulase negative Staphylococci, 2 (5.00%), Klebsiella oxytoca, 1 (2.50%), Enterococcus cloacae, 1 (2.50 %). While twenty (20) isolates, Escherichia coli, 8 (37.5 %), Pseudomonas aeruginosia, 5 (25%), Staphylococcus aureus, 4 (18.75 %), Proteus vulgaris, 2(12.5 %), Coagulase negative Staphylococci, 1 (6.25%) respectively were isolated from non pregnant women. Urinary Tract Infection occur more in female than male, and it is also rampant in pregnant women. The antibiotic susceptibility pattern shows that Ofloxacin and Nitrofuratoin are the best antimicrobial agent used in treating bacteriuria in this study. The antibiotic susceptibility pattern on Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Proteus spp shows that quinolone with percentage susceptibility responses of 89.23%,84.54%, 90.57% and 88.12% were most effective antibiotics while Pseudomonas aeruginosa and Staphylococcus aureus shows very high resistant responses (100 %) to Ampicillin and Amoxicillin in some instances.

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