World Journal of
Pharmaceutical and Life Sciences

NEUROINFLAMMATION IN THE PATHOGENESIS OF NEURODEGENERATIVE DISEASE. A RATIONAL FRAME WORK FOR THE SEARCH OF NOVEL THERAPEUTIC APPROACH

Abhishek Marwari, Ashish Kumar Verma*, Salman, Pooja Rani, Mohit kumar, Kamal Jeet, Shalu Chauhan, Ankit Tyagi

ABSTRACT

Neuroinflammation appears to occur as a consequence of a series of damage signals, including trauma, infection, oxidative agents, redox iron, oligomers of ? and ?-amyloid, etc. In this context, our theory of Neuroimmunomodulation focus on the link between neuronal damage and brain inflammatory process, mediated by the progressive activation of astrocytes and microglial cells with the consequent overproduction of proinflammatory agents. Here, we discuss about the role of microglial and astrocytic cells, the principal agents in neuroinflammation process in the development of neurodegenerative diseases.

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