World Journal of
Pharmaceutical and Life Sciences

FORMULATING FAST DISINTEGRATING ZINC TABLET USING SINGLE STRUERS LABOPRESS-1

Okey-Mbata Chioma Chinyere* Keatch Robert, Igwe Chidi and Ukairo Doris

ABSTRACT

The purpose of our research work was to formulate tablets of zinc as a nutritious element by direct compression method employing different disintegrants and ascorbic acid as an antioxidant at different proportions in addition to other excipients used in tablet formulation, in order to enhance the disintegration/dissolution rate as well as the percentage drug release. Pre-compression parameters which include bulk and tapped densities, Carr’s index, Hausner’s ratio were evaluated and found to be within acceptable limits. Weight variation, hardness, friability, disintegration time, and in vitro dissolution profile of the formulated tablets were evaluated. Following the data obtained from the dissolution study carried out in 900ml phosphate buffer of 0.05M, 6.8 pH at 37±1?C, the best batch was found to formulations in batch I; because the formulations in this batch I were able to release 99.8% of the drug within 10 minutes. Furthermore, the data obtained were analyzed and found to be significantly difference at p<0.05.

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