World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

ASSESSMENT OF MODIFIED FENUGREEK ON BLOOD SUGAR LOWERING ACTION IN RATS

Prabir K. Sinha Mahapatra, Subhas C. Mandal, Alok K. Hazra and Tapas K. Sur*

ABSTRACT

The present study was designed to compare the antidiabetic potentialities between standardized fenugreek powdered seed (FG) are modified fenugreek (FGM). HPTLC chromatographic fingerprint of both the samples were determined. Anti-hyperglycaemic activities of test drugs were evaluated on alloxan induced (120 mg/kg, i.p) diabetic rats. The glucose, cholesterol and triglycerides in blood were monitored. FGM (50-150 mg/kg, p.o) exhibited best potentiality in reducing blood glucose within 14 days treatment in comparison with FG. FGM also significantly (p<0.5) negated elevations of lipid profile in diabetic rats. The observed effects were also comparable with Glibenclamide (5 mg/kg). The present observation identified FGM for anti-hyperglycaemic and lipid lowering actions and substantiates its uses on diabetic population.

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