Abstract
FORMULATION AND EVALUATION OF LYCOPENE NIOSOMES WITH SPECIAL EMPHASIS ON STABILITY
Ganesh N.S*, K. Bhagya Lakshmi and Vineeth Chandy
ABSTRACT
The objective of the work was to formulate and evaluate lycopene niosomes with special emphasis on stability. Niosomes was prepared by thin layer hydration and ether injection method using cholesterol, span 20, span 60. The drug-polymer incompatibility was carried out by FTIR studies. The formulated niosomes were then incorporated into 1% Carbopol gel for topical administration. Evaluation studies like drug content, entrapment efficiency, spredability, and in-vitro permeation release studies were performed. From the FTIR studies, the drug-polymers compatibility was confirmed, that the polymer did not interfere with the drug used. Entrapment efficiency varied from 58.56 to 98.92 %. The most ideal formulation was F3 since it showed good In vitro permeation release of 94.65 % at the end of 12 hours. From this study it could be concluded that the formulated Lycopene niosomal gel showed good and effective release.
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