World Journal of
Pharmaceutical and Life Sciences

DIVERSE CLINICAL FUNCTIONS OF SERINE PROTEASE AND ITS INHIBITORS

Waseem Abid, Dr. Sikander Ali*, Ali Javed and Nasir Ali

ABSTRACT

Serine protease performs normal biological functions in cell. Serine protease are involves in coagulation, inflammation and immunity. Wide variety organisms produce serine proteases including virus, bacteria, animals and plants. Serine proteases are mono-meric enzymes. Serine protease are produced as inactive enzymes called zymogen and transported to other organs where they needed, which are then be cleaved and activated in those organs. They have a key role in malignancy as different carcinoma cells produced serine protease to promote Tumor growth. Malignant cells also produce serine protease inhibitor to protect the tumor cells from proteolysis. Malignant cells with serine protease expression have a very poor prognosis. Serine proteases are involved in inflammation. They serve as chemo-attractant for different pro-inflammatory cells and also involves in cleavage and activation of different pro-inflammatory cytokines. Serine proteases are also produced by different pathogens and helps pathogens in adherence and biofilm formation inside the host and increase pathogenicity. Serine protease inhibitors are very important in order to stop the abnormal proteolysis generate by serine protease. Serine protease inhibitors are also produced by a wide variety of organisms. Serine protease inhibitors involve in the enhancement of immunity by protecting the memory T cells from program cell death.

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