World Journal of
Pharmaceutical and Life Sciences

CARICA PAPAYA: A FRUITFUL ALTERNATIVE AGAINST PERIODONTOPATHOGENS ??

Ravi Tejeshwar Reddy*, Vandana K.V and Shobha Prakash

ABSTRACT

Papaya (carica papaya linn.) contains broad spectrum phytochemicals of nutritional and medicinal importance like polysaccharides, vitamins, minerals, enzymes, proteins, alkaloids, glycosides, lectins, saponins etc. which may be accountable for its antimicrobial property. So the objective of this study is to assess and study antimicrobial efficacy of phytochemicals extracted from papaya fruit and leaf on periodontal pathogen. Aqueous and ethanolic extracts of unripe papaya fruit and leaves are made respectively and the extracts have been tested for their antimicrobial activity on the cultures of various periodontal pathogens in vitro by well dilution method. and the results are, the MIC for aggregatibacter actinomycetemcomitans with ethanolic fruit extract, aqueous fruit extract, ethanolic leaf extract and aqueous leaf extract was 25?g/ml, 25?g/ml, 25?g/ml & 50?g/ml respectively. MIC for porphyromonas gingivalis with ethanolic fruit extract was 25?g/ml with aqueous fruit extract, ethanolic leaf extract 50?g/ml and with aqueous leaf extract it showed resistance throughout. MIC for Prevotella intermedia with ethanolic fruit extract and ethanolic leaf extract was 75?g/ml, with aqueous leaf extract MIC was 50?g/ml and with aqueous fruit extract it showed resistance throughout. MIC for fusobacterium nucleatum with ethanolic fruit extract and ethanolic leaf extract was 10?g/ml, with aqueous fruit extract MIC was 75?g/ml and with aqueous leaf extract it showed resistance throughout. This concludes that the phytochemicals extracted from unripe papaya fruit and leaves has antimicrobial effect on A.actinomycetemcomitans, P.gingivalis, P.intermedia, F.nucleatum.

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