World Journal of
Pharmaceutical and Life Sciences

THE IMPACT OF NANO-SUSPENSIONS ON DRUG DELIVERY: ENHANCING SOLUBILITY AND THERAPEUTIC EFFICACY

Rishika Srivastav*, Rajesh Vooturi, Jagadeesh Nadigoti, Veena Vithalapuram and Earati Surender

ABSTRACT

At large, poor aqueous solubility remains a significant challenge in drug development and formulation limiting bioavailability and therapeutic efficacy. The formulation is deemed successful when it achieves the desired solubility and better bioavailability of the drug, which is important for pharmacological responses. However, 40 percent of newfound chemical entities (NCEs) industrialized by the pharmaceutical industry are primarily lipophilic and exhibit poor water solubility which result in various challenges in the development and formulation of BCS class II & IV. Nanosuspension, a sub-micron colloidal dispersion of nano-sized drug particles becomes a promising solution to overcome these issues. It involves various techniques top-down (Media milling, High-pressure homogenization) and bottom-up (precipitation, supercritical fluid) technology. In the formulation of nanosuspension excipients, a critical consideration is vital for excipients categories like stabilizers, surfactants, co-surfactants, buffers, preservatives are used for the better output of the product. Characterization of nanosuspension is essential to assess the quality and performance. This review emphasizes various pros and cons, emphasizing the applications of nanosuspensions.

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