World Journal of
Pharmaceutical and Life Sciences

DEVELOPMENT AND EVALUATION OF BIODEGRADABLE SUSTAINED RELEASE TABLET FORMULATION OF ANASTROZOLE INTENDED TO TREAT BREAST CANCER

Bhavani Reddy Y.*, Suresh Kumar J. N., Mahesh A., Khasimbee N., Ashok K., Teja V., Joshna Priya V.

ABSTRACT

Breast cancer is a leading cause of cancer-related mortality among women, with over 1.5 million new cases diagnosed annually. Risk factors include age, genetics, dense breast tissue, hormonal influences, and lifestyle choices. Anastrozole, an aromatase inhibitor, is widely used for treating hormone receptor-positive breast cancer in postmenopausal women. It works by selectively inhibiting the aromatase enzyme, reducing estrogen production, and slowing tumor growth. This study focuses on the formulation and evaluation of sustained-release Anastrozole tablets using the wet granulation method. Various excipients, including fillers, disintegrants, lubricants, and glidants, were used to optimize tablet characteristics. Granules were evaluated for flow properties such as angle of repose, bulk density, and compressibility index, ensuring uniform tablet production. The formulated tablets were assessed for physical parameters, including hardness, friability, weight variation, disintegration, and dissolution rate. The results demonstrated that all formulations met standard pharmaceutical requirements, with good flowability, uniform hardness, low friability, and effective dissolution profiles. In-vitro dissolution studies showed sustained drug release over 12 hours, with formulations achieving up to 99.15% cumulative drug release. These findings confirm that the developed sustained-release Anastrozole tablets offer controlled drug release, potentially improving therapeutic efficacy and patient compliance. In conclusion, the formulated tablets provide a promising approach for breast cancer treatment, ensuring prolonged drug action and stable plasma concentration levels. Further in-vivo studies are recommended to validate the clinical efficacy of the sustained-release formulation.

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