World Journal of
Pharmaceutical and Life Sciences

REVIEW ON IN VITRO TESTS FOR PREDICTING DRUG – DRUG INTERACTIONS

Vasavi Pachika*, Vijaya Sindhuri Gopu and Srinivas Reddy Devireddy

ABSTRACT

Prediction of drug-drug interactions from in vitro studies have become rapidly expanding in field of research. Over the last 20–30 years our understanding of drug metabolism in man has greatly increased to accumulate knowledge and to the use of in vitro and even in silico models. Several In vitro & In silico models are proposed for assessing drug interactions. Although the models can easily predict the type, mechanism, and even magnitude of interactions, they often fail to predict the clinical consequences. The main goal of these tests is to eliminate as early as possible those molecules which would fail during development, so as to develop only those products which are reasonably likely to succeed. Ideally, sufficient information on potential drug interactions should be obtained before a compound is selected for development. In this context, information from in vitro inhibition studies has become important in choosing new candidate drugs for development.

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