World Journal of
Pharmaceutical and Life Sciences

KETOCONAZOLE LOADED MICROSPHERES: A NOVEL WEAPON FOR ORAL CANDIDIASIS

Dr. P. Premkumar, Nikhila M. Nair*, Jency Abraham and Dr. Shajan A.

ABSTRACT

Ketoconazole is an antifungal medication.Ketoconazole prevents the fungus from growing on the skin. The parameters’ affecting the morphology and other characteristics of the resultant products is carried out by Scanning Electron Microscopy (SEM). Drug loaded microsphere has shown that encapsulation and controlled release of Ketoconazole could reduce the side effect while also reducing percutaneous absorption when administered through mucus membrane. The particle size ranged from 30-120μm. The microspheres were incorporated in various concentration of gel formulation and the drug release from these formulations was up to 12 hours. Candidiasis describes a group of yeast like fungal infections involving the skin and mucus membrane. Infection is caused by candida species, typically Candida Albicans. The candidiasis is seen orally in people with altered oral ecology (from dental appliances, hypo salivation or the use of immunosuppressive treatment. Person with HIV or AIDS, or other cellular immune defects) with the high prevalence and opportunistic nature, it is one of the most common infections found in the oral cavity, especially in the geriatrics. Due to asymptomatic nature of the infection and negligence by clinicians during the examination. It is one of the frequently missed pathology. The aim of the review is to enumerate in detail the various type epidemiology and management of oral candidiasis.

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