World Journal of
Pharmaceutical and Life Sciences

A COMPREHENSIVE REVIEW OF DRUG NANOCRYSTALS: ITS FORMULATION METHODS AND CHARACTERIZATION TECHNIQUES

Dr. P. Premkumar*, Jency Abraham, Nikhila M. Nair, Dr. Shajan Abraham and Gomathi A. R.

ABSTRACT

The poor solubility of drug is a major problem which limits the development of highly potent pharmaceuticals. The drugs with low solubility lead to low oral bioavailability and erratic absorption which is particularly pertinent to drugs within class II of the Biopharmaceutical Classification System (BCS). Generally, the rate-limiting step for absorption of the drugs in this class is the dissolution velocity arising from low solubility. Although the drugs are high permeability, the poor solubility results in a low concentration gradient between gut and blood vessel consequent to a limitation of drug transport and oral absorption.

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