World Journal of
Pharmaceutical and Life Sciences

CORRELATION BETWEEN AGE AND HISTOLOGICAL GRADE OF PROSTATE CANCER AT A TERTIARY HOSPITAL, SOUTH -SOUTH NIGERIA

*Ugwa Okezie Chinedu, Amadi Darlington Chidi, Danagogo Okigbeye

ABSTRACT

Prostate cancer is the third leading cancer in men. There is paucity of data in Nigeria on prostate cancer vis-a-vis the new International Society of Urological Pathology (ISUP) grading system for prostate cancer started in 2014. The objective of the study is to examine the age of the patients diagnosed of prostate cancer in University of Port Harcourt Teaching Hospital between January 2019 and June 2022, the histological type, Gleason scores and ISUP grade of the prostate cancer cases and to correlate these with age. Histopathological slides were retrieved and reviewed; relevant data were extracted from the Laboratory Information Systems, Laboratory Requisition Forms and the departmental ledger where necessary. The data were statistically analysed. A total of 208 patients were diagnosed of prostate cancer during the study period. The meanage of the patients at diagnosis was 68.54 years, with the lowest recorded age being 49 years, while the highest age was 91 years. The most common age bracket was 60 – 69 years(35.1%). All the cases reviewed were acinar type of prostatic adenocarcinoma with commonest primary score jointly been 3 and 5 while the commonest secondary score was 4. Grade 5 was the major ISUP grade representing 44.7% of the cases. There is no correlation between age and either the Gleason scores or the ISUP grades.

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