World Journal of
Pharmaceutical and Life Sciences

IN-SILICO AND IN-VITRO ASSESSMENT STUDY OF ANTI- MICROBIAL, ANTI-INFLAMMATORY ACTIVITY OF NAPROXEN TOPICAL GEL

Nabamita Sen*, Fowad Khurshid, M. Ganga Raju, Maddu Ramya Sree, Rodda Prasanna Tulasi and Ch. Charmi

ABSTRACT

Introduction: Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) primarily used to reduce inflammation, pain, and fever by inhibiting the enzymes COX-1 and COX-2, which are involved in prostaglandin production. This action helps alleviate symptoms of inflammatory conditions like arthritis and musculoskeletal injuries. While naproxen is not directly antimicrobial, some studies suggest it might enhance the effectiveness of antibiotics by reducing inflammation or disrupting bacterial biofilms, though this is still an area of ongoing research. Its main therapeutic benefit remains its anti-inflammatory and analgesic properties. Methods: Basic polymer carbopol934 was used to prepare topical gel included with methanol extract of naproxen, anti-microbial activity was performed by checking ZOI in which marketed naproxen gel has taken as control group and anti-inflammatory activity by egg denaturation assay by taking Diclofenac as control group. Results: ZOI of formulation at 1000 μg/ml is 19mm and marketed formulation is 15 mm which shows the plain naproxen formulation shows more anti-microbial activity, anti-inflammatory activity was observed well in naproxen formulation (90%) rather than in diclofenac (1.4). Conclusion: This study was concluded that naproxen has high anti-inflammatory activity also mild anti-microbial activity.

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