World Journal of
Pharmaceutical and Life Sciences

SITE SPECIFIC DRUG DELIVERY OF CIPROFLOXACIN HYDROCHLORIDE NANOPARTICLES FOR IMPROVISED TREATMENT OF PERIODONTITIS

Dr. Rakesh Parmar* and Swati Kashyap

ABSTRACT

Periodontitis, commonly known as gum disease, is a significant infection of the gums where both the gums and the deeper structures supporting the teeth become inflamed. This condition manifests as redness, swelling, and a propensity for gums to bleed when brushing, all caused by bacteria that accumulate on the surface of the teeth. In more advanced stages, it can lead to sore and bleeding gums, difficulties in chewing, and potentially result in tooth loss. Approximately 20-50% of the global population in both developed and developing nations is affected. The prevalence of periodontitis is notably high among adolescents, adults, and older individuals, making it a pressing public health issue. The aim of this study is to develop nanoparticles of ciprofloxacin hydrochloride that can address the challenges of administering the medication systemically for periodontal disease. Targeted drug delivery of ciprofloxacin hydrochloride can ensure that the medication reaches the affected area effectively over an extended period without causing side effects. Ciprofloxacin hydrochloride nanoparticles were synthesized employing the ionotropic gelation technique with 1.5% glacial acetic acid. An orthogonal factorial design was utilized to formulate the nanoparticles. Characterization of the nanoparticles was conducted to assess particle size, zeta potential, percentage of drug loading, and drug entrapment efficiency. Scanning Electron Microscopy (SEM) was used for surface analysis of the nanoparticles. The in-vitro drug release profile of nine different batches was evaluated using the Franz Diffusion Cell method, and for the batch with the smallest particle size, an in-vitro antimicrobial assay was performed using the turbidimetric approach. Ciprofloxacin hydrochloride nanoparticles served as a superior carrier compared to other antibacterial medications, demonstrating effective and extended drug action lasting up to 168 hours.

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