World Journal of
Pharmaceutical and Life Sciences

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Life Sciences
An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)
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Abstract

FABRICATION & ASSESSMENT OF HERBAL ALOE VERA MULTIPURPOSE GEL

*Tanay Upadhyay and Dr. Surendra Pardhi

ABSTRACT

The objective of the study is to fabrication & assessment of herbal aloe vera multipurpose gel containing leaf extract of Aloe vera, Neem & Tulsi, for their anti-ageing &anti-septic activity in rats. 12 herbal gel formulations were prepared using 1.5% of gelling agents carbopol 934 (F1-F6) and carbopol 940 (F6-F12) and they were evaluated for physical appearance, net content, viscosity, extrudability, pH, spreadability, in vitro diffusion profile and primary skin irritation tests. The stability study for the topical herbal gel formulation was done for 3month at 25ºC±2 ºC/60%RH±5%RH, 32ºC±2 ºC/60%RH±5%RH, 40ºC±2 ºC/60% RH±5%RH and Assessment of microbial load were also carried out. Formulated gels were homogenous, stable and complied with the guidelines. Among the formulations, F4 showed better release (98.4 %) characteristics than other formulations. No erythema or edema was observed in the skin irritation test confirming the gel was non-toxic and safe.

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