World Journal of
Pharmaceutical and Life Sciences

THE DARK SIDE OF MEDICATIONS: HOW CERTAIN DRUGS CAN CAUSE DEMENTIA

Dr. D. K. Suresh*, P. Shobha, G. Vyshanavi, A. SaiNadh, D. Sathwika

ABSTRACT

Dementia is a devastating neurodegenerative disorder affecting millions worldwide. While age, genetics and lifestyle factors contribute to dementia risk; certain medications have been implicated in its development. This review aims to summarize the current evidence on drug-induced dementia, highlighting the most commonly implicated medications and their mechanisms of action. Anticholinergic medications, benzodiazepines and antipsychotics were consistently associated with increased dementia risk. Additionally, certain antidepressants, antihistamines and cardiovascular medications were also implicated. Epidemiological study also clearly states that worldwide nearly 50 million people suffering from dementia and nearly 10 million new cases diagnosed each year. The underlying mechanism of drug-induced dementia are complex and multifaceted, involving neurotransmitter dysregulation, oxidative stress, and inflammation. Our findings highlight the need for healthcare providers to carefully consider the potential risk and benefits of medications.

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