World Journal of
Pharmaceutical and Life Sciences

ORALLY FAST DISSOLVING STRIPS: A NEW APPROACH TO ORAL DRUG DELIVERY SYSTEM

Dhanshree B. Kadam*, Anulata A. Sathe, Ritu D. Jaiswal, Komal P. Mohanapure, Sonu S. Tonge, Rushikesh D. Wanole and Dr. Manisha D. Kitukale

ABSTRACT

Mouth Dissolving Films (MDFs) are an innovative and emerging drug delivery system designed to dissolve quickly upon contact with saliva, offering ease of administration and improved patient compliance. These thin, flexible strips are particularly beneficial for pediatric, geriatric, and dysphagic patients who face difficulties swallowing conventional tablets or capsules. MDFs deliver drugs through oral mucosal absorption or gastrointestinal pathways, ensuring rapid onset of action. The formulation of MDFs typically involves hydrophilic polymers like hydroxypropyl methylcellulose, polyethylene glycol, or polyvinyl alcohol, which provide the necessary mechanical strength and dissolvability. The films are prepared using techniques such as solvent casting, hot-melt extrusion, or rolling methods. The incorporation of active pharmaceutical ingredients, plasticizers, sweeteners, and flavoring agents is crucial for achieving desired drug release profiles, film stability, and patient acceptability. Key advantages of MDFs include precise dosing, portability, and avoidance of first-pass metabolism, making them ideal for both systemic and local drug delivery. However, challenges like limited drug loading capacity, taste masking, and ensuring film uniformity and mechanical integrity require optimization during formulation development. This review highlights the critical aspects of MDFs, including their formulation, manufacturing techniques, evaluation parameters, and applications. Recent advancements, such as the use of nanotechnology and bio-adhesive polymers, have expanded the scope of MDFs for delivering a wide range of therapeutic agents. As a patient-friendly alternative, MDFs hold great promise for improving medication adherence and therapeutic outcomes. Further research is warranted to overcome existing limitations and explore novel applications.

[Full Text Article]   [Download Certificate]