World Journal of
Pharmaceutical and Life Sciences

OCULAR DRUG DELIVERY SYSTEM: CURRENT SCENARIO AND FUTURE PERSPECTIVES

Pallavi Tembhare*, Saurabh Kotangale, Prameshwar Wankhede, Tulsidas Nimbekar and Dilip Sanghi

ABSTRACT

Ocular drug delivery's distinct anatomy and physiology have presented pharmacologists and drug delivery experts with significant challenges. Delivering a drug alone or in a dosage form is made extremely difficult by the combination of static barriers (the various layers of the cornea, sclera, and retina, including blood aqueous and blood–retinal barriers), dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution), and efflux pumps, particularly to the posterior segment. In recent years, there has been a growing movement to identify influx transporters on different ocular tissues and develop a parent drug delivery system that targets these transporters. To get over a variety of static and dynamic obstacles, colloidal dosage forms such liposomes, nanoparticles, nanomicelles, and microemulsions have been extensively studied in parallel. To maintain drug levels at the target region, innovative drug delivery techniques such fibrin sealant-based methods and bioadhesive gels were created. Drug delivery may be significantly improved in the years to come by developing noninvasive sustained drug delivery methods and investigating the viability of topical application to deliver medications to the posterior section. Today's advancements in ocular medication delivery hold great promise for addressing the difficulties presented by a variety of anterior and posterior segment disorders.

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