World Journal of
Pharmaceutical and Life Sciences

ANTIDIABETIC ACTIVITY OF ETHANOLIC EXTRACT OF PHYLLANTHUS VIRGATUS IN STREPTOZOTOCIN AND HIGH FAT DIET INDUCED DIABETIC RATS

Golla Siva Kumar, J.Kondal Reddy*, Srikanth Reddy, Aparna Nukala, S.Mehathaj

ABSTRACT

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia and alterations incarbohydrate, fat and protein metabolism, associated with the continuous destructionof ?-cell leads to the disturbance inglucose homeostasis. Liver and pancreas are the two main organs which plays important role in maintaining the glucose level by regulating alternative pathways between glucose uptake and gluconeogenesis (Ferreet al., 1996). Diabetes is induced by streptozotocin (STZ) in animal model. Currently available drugs for the treatment of Diabetes mellitus have a number of limitations, such as adverse effects and a high rate of secondary failure Although there is a growing trend towards using natural remedies adjunct to conventional therapy, traditionally used plants might providea useful source of new hypoglycemic compounds. Although Phyllanthus virgatus may be described as a medicinal plant used for various purposes, no scientific reports exist on its antihyperglycemic effect.

[Full Text Article]   [Download Certificate]