World Journal of
Pharmaceutical and Life Sciences

DEVELOPMENT AND EVALUATION OF ETHANOL EXTRACT FROM CARICA PAPAYA IN VARIOUS DOSAGE FORMS: LOZENGES, SYRUP, AND SANITIZER GEL

R. Kokila*, V. Kalvimoorthi, M. Rajasekaran, L. Gopi, M.Pharm and K. Kaveri

ABSTRACT

This study focuses on the formulation of various dosage forms containing Carica papaya, including solid (lozenges), liquid (syrup), and semi-solid (sanitizer gel) preparations. The ethanol extract of Carica papaya leaves was prepared using 90% ethanol. Lozenges were formulated using the heating and congealing method, with excipients such as agar, acacia, tragacanth, peppermint oil, and sucrose. These lozenges were evaluated for weight variation, hardness, friability, drug content, disintegration time, and in vitro dissolution, with the HL1 formulation releasing 98.49% of the drug in 35 minutes. For the syrup, bases like water, simple syrup, and honey were used, incorporating excipients such as hydroxyl ethyl cellulose and peppermint oil. The syrup underwent sensory evaluation, TLC analysis, viscosity, pH, and stability testing, all of which met standard limits. The sanitizer gel was formulated using HPMC polymer, with excipients like SLS, methyl and propyl parabens, and glycerin. The gel was evaluated for irritation, pH, viscosity, foam height, and foam time, all of which were within acceptable limits. All dosage forms containing Carica papaya were successfully prepared and evaluated, demonstrating promising characteristics for potential therapeutic use.

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