World Journal of
Pharmaceutical and Life Sciences

REVIEW ON SUBSTITUTED 1,2,4 -TRIAZOLES AS POTENT ANTI-FUNGAL AND ANTI-VIRAL AGENTS

Dr. Subhas Sahoo*, K. Sindhoori*, S. Deekshitha, V. Sai Samrat, H. Akshaya, Aminul Islam and D. Kamal

ABSTRACT

For the past few decades, modification of 1,2,4-triazole nucleus have made a tremendous significance in medicinal chemistry. 1,2,4-triazoles and their derivatives are found to have wide variety of pharmacological uses. From literature survey it is well known that triazole heterocycles exhibit manifold importance in the field of medicinal chemistry as a potent chemotherapeutic agent. Triazole is a synthetically versatile substrate used for the synthesis of a large variety of heterocyclic compounds, such as triazole fused with thiadiazole, oxadiazole, and has a raw material for drug synthesis. Much work has been carried out on triazoles as potent antifungal and antiviral agents and many drugs with triazole nucleus having antifungal properties have come into the market (e.g. Voriconazole, Itraconazole, Fluconazole, derivatives) as well as having antiviral properties (e.g. ribavirin, doravirin, derivatives) and their pharmacological profiles which may contribute in future to synthesize various analogs and to develop new pharmacologically less toxic medicines.

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