World Journal of
Pharmaceutical and Life Sciences

A RETROSPECTIVE OBSERVATIONAL STUDY ON THE ANTIBIOTIC PROPHYLAXIS AND INDICATION OF C-SECTION IN A TERTIARY CARE HOSPITAL

Okezie Chioma Hope*, S. Abida Khanam, Maheen Farha, Pavan Chouhan, K. Vishalakshi and A. Sudheer Kumar

ABSTRACT

Cesarean Section (CS) deliveries are among the most frequently performed surgical procedures worldwide, aimed at improving maternal and neonatal outcomes in high-risk pregnancies. This retrospective observational study evaluates 150 CS cases conducted at a tertiary care hospital between 31st May 2022 and 1st June 2024, with a focus on indications, prophylactic antibiotic use, and outcomes. The leading indications for CS were severe oligohydramnios (26%), cephalopelvic disproportion (17.2%), and fetal distress (11%). Prophylactic IV antibiotics, primarily ceftriaxone, were administered to 73% of patients within 30 minutes before surgery, significantly reducing postoperative infections. Neonatal outcomes indicated 72% preterm births and 53.3% low birth weight, with minimal NICU admissions (8.6%). The study underscores the critical role of timely antibiotic administration and identifies opportunities for optimizing CS protocols to enhance patient care.

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